The Role of Protein Kinase A in the Action of Activation-induced Deaminase

The Role of Protein Kinase A in the Action of Activation-induced Deaminase

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DNA cytosine deaminases are a newly discovered class of enzymes that convert cytosines in DNA to uracil. Human activation-induced cytidine deaminase (AID) plays a key role in antibody maturation in vertebrates. There are three major genetic events by which antibodies acquire their specificity. They are somatic hypermutation (SHM), Class switch recombination (CSR) and gene conversion (GC). Approximately 10 to 15% of AID expressed in B cells is reported to be phosphorylated at Ser38. However, Biological role of AID phosphorylation is controversial, especially with respect to ability of AID deamination.The cells were then transferred to pre-chilled sterile conical tubes and Eppendof centrifuge 5810 at 4AdC. Cells were ... of the overnight culture using a plasmid isolation kit (Eppendorf Perfectprep) and following the manufacturersa#39; instructions .


Title:The Role of Protein Kinase A in the Action of Activation-induced Deaminase
Author:
Publisher:ProQuest - 2008
ISBN-13:

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